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Postby Margaret » Mon Oct 18, 2010 3:06 pm

Good Afternoon Helpline

We have read a report in today's Daily Mail of the Fenretinide (Retinol) clinical trials at New York University School of Medicine and the promising results for treatment of dry AMD

Have you any further information and/or an opinion on this?

Kind Regards

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Postby helpline » Tue Oct 19, 2010 9:01 am

Dear Margaret,

We at the Society first heard about Fenretinide in 2008, and reported briefly on it in our annual Digest journal.

This is potentially an exciting development, but the manufacturers have only just completed a phase II trial. The phase III trials will not start for another 12-18 months. Indications are that Fenretinide is helping to significantly slow the progress of Dry MD; it will not repair and save dying eye cells, but seems to prevent further deterioration.

The other encouraging development is that it appears to halve the incidence of Wet MD in patients.

Availability as a treatment is probably 5 years away at the moment assuming all the trial results are positive.

I am afraid that at this stage we cannot add much more than is published by the Mail under the following link;

http://www.dailymail.co.uk/health/artic ... older.html

The following is further information which we found courtesey of the website of the 'US National Neurovision Research Institute' -

''Fenretinide, a drug that slowed the progression of dry age-related macular degeneration (AMD) in a Phase II clinical trial, has also reduced the incidence of wet AMD by 50 percent in that same clinical study. The initial dry AMD results from the clinical study were presented in spring 2009. Full two-year results were announced on September 1, 2010.

“The dual effect of fenretinide in these clinical trials is impressive,” says Stephen Rose, Ph.D., chief research officer, Foundation Fighting Blindness. “Virtually everyone who has AMD starts off with the dry form. Fenritinide shows potential for preventing vision loss whether a person’s condition progresses to advanced dry AMD or into wet AMD.”

Researchers report that fenretinide not only reduces the size of lesions and build-up of toxins associated with vision loss in dry AMD, but also the expression of vascular endothelial growth factor, or VEGF, a protein which causes the formation of unhealthy, leaky blood vessels that lead to severe vision loss in people with wet AMD.

The Foundation funded earlier preclinical studies of fenretinide, which demonstrated the drug’s potential for slowing vision loss in people affected by Stargardt disease, Best disease, and other conditions characterized by the buildup of toxic waste products in the retina.

ReVision Therapeutics, an ophthalmic biopharmaceutical company in San Diego, is hoping to launch a Phase III clinical trial of fenretinide for the treatment of AMD in 12-18 months.''

We cannot comment further at this stage, but will report progress in either our annual Digest journal or our quarterly Side View magazine.


The Helpline Team (Andy, Jayne, Ann and Pete)
The Macular Disease Society
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Postby Margaret » Tue Oct 26, 2010 12:13 pm

Dear Andy

Many thanks for detailed reply - am briefly using computer at the library so will print it out for my husband

Even a little ray of hope is worth something!

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